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Chronic hepatitis B virus persistence: Mechanisms, consequences and implications for achieving cure

Christopher Georgi1, Simmone D'souza2, Carla Osiowy3

  • 1Ottawa Hospital Research Institute, Canada.

Annals of Hepatology
|June 28, 2025
PubMed
Summary

Hepatitis B virus (HBV) persists in hepatocytes via covalently closed circular DNA (cccDNA) and integrated DNA, hindering a cure. New therapies aim to disrupt these persistent viral forms for chronic Hepatitis B infection.

Keywords:
Functional cureHBV DNA integrationHepatitis B infectionSterilizing cureViral persistencecccDNA

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