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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Sep 17, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Mohs Micrographic Surgery for Melanoma.

Joshua Burshtein1, Justin Marson2, Milaan Shah3

  • 1Department of Dermatology, University of Illinois-Chicago, Chicago, IL, USA.

Dermatologic Clinics
|June 28, 2025
PubMed
Summary

Mohs micrographic surgery (MMS) offers a tissue-sparing approach for skin cancer treatment. Evidence suggests MMS may lower melanoma recurrence rates, particularly with immunostaining, though challenges exist.

Keywords:
Fixed tissueFresh tissueImmunostainingMelanomaMohsSurgeryTissue sparing

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Area of Science:

  • Dermatology
  • Surgical Oncology

Background:

  • Mohs micrographic surgery (MMS) is a specialized tissue-sparing technique for cutaneous malignancies.
  • Guidelines recommend wide local excision for noninvasive melanoma.
  • MMS is considered for specific melanoma subtypes like in-situ and lentigo maligna.

Purpose of the Study:

  • To explore the evidence supporting Mohs micrographic surgery for melanoma treatment.
  • To discuss the challenges associated with using MMS for melanoma.

Main Methods:

  • Review of existing literature on Mohs micrographic surgery for melanoma.
  • Analysis of recurrence rates and the role of immunostaining.

Main Results:

  • Mohs micrographic surgery (MMS) shows potential for lower melanoma recurrence rates.
  • Immunostaining may enhance the effectiveness of MMS in melanoma treatment.

Conclusions:

  • MMS is a viable option for select melanoma cases, including melanoma-in-situ and lentigo maligna.
  • Further exploration of MMS benefits and challenges in melanoma management is warranted.