Pellicle engineering with CaneCPI-5: a scoping review

Area of Science:

• Biomaterials Science
• Oral Biology
• Dental Research

Background:

• The salivary pellicle is crucial for dental surface protection against erosion and bacterial adhesion.
• CaneCPI-5, a sugarcane-derived peptide, is a potential agent for modifying the salivary pellicle.
• This review assesses CaneCPI-5's efficacy in pellicle engineering for oral health.

Purpose of the Study:

• To evaluate the potential of CaneCPI-5 in modifying the salivary pellicle.
• To assess its effectiveness in preventing dental erosion.
• To investigate its impact on bacterial adhesion to dental surfaces.

Main Methods:

• A scoping review of studies on CaneCPI-5's effects on human saliva-derived pellicles.
• Literature search conducted in Medline, Scopus, and Web of Science up to May 2025.
• Inclusion of 20 English-language research articles focusing on enamel and dentin pellicles.

Main Results:

• CaneCPI-5 binds to enamel and modifies pellicle proteins, enhancing erosion resistance.
• Effects on bacterial adhesion and caries prevention were inconsistent.
• Synergistic effects observed with agents like vitamin E, but overall results were mixed.

Conclusions:

• CaneCPI-5 shows promise for improving pellicle's erosion protection.
• Evidence is limited, and findings on bacterial adhesion are inconclusive.
• Further research under clinical conditions is needed to confirm efficacy and long-term applicability.