Related Experiment Video
Updated: Sep 17, 2025

Translational Rabbit Model of Chronic Cardiac Pacing
Published on: January 6, 2023
Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation
Sudhanshu Kumar Dwivedi1, Akhil Sharma1, Gaurav Chaudhary1
1Department of Cardiology, King George's Medical University, Lucknow, India.
Insights
Serial echocardiography aids early detection of cardiac perforation and tamponade during transvenous temporary pacing. Renal dysfunction and longer pacing duration are key predictors of these serious complications.
Area of Science:
- Cardiology
- Medical Imaging
- Interventional Cardiology
Background:
- Cardiac perforation (CP) and cardiac tamponade (CT) are rare but serious complications of transvenous temporary pacing (TTP).
- The diagnostic utility of serial echocardiographic imaging for detecting these complications requires further investigation.
Purpose of the Study:
- To determine the incidence of CP and CT following TTP.
- To assess the temporal development of CP and CT.
- To identify predictors of CP and CT.
Main Methods:
- A prospective, observational study involving 641 patients undergoing TTP at a tertiary care hospital.
- Serial echocardiographic evaluations were performed at multiple predefined time points.
- Univariate and multivariate Cox regression analyses were used to identify predictors.
Main Results:
- Cardiac perforation (CP) occurred in 9.2% of patients.
- Serial echocardiography detected new effusions at various time points post-TTP.
- Renal dysfunction and longer TTP duration were significant predictors of CP.
Conclusions:
- Routine serial echocardiographic imaging improves early detection of CP and CT during TTP.
- Identifying predictors like renal dysfunction and pacing duration can inform risk stratification.
Background:
Cardiac perforation (CP) and cardiac tamponade (CT) are rare but dreaded complications of transvenous temporary pacing (TTP), with variable reported incidences and impacts on morbidity and mortality. The role of serial echocardiographic imaging in accurately detecting these complications has not been comprehensively investigated.
Objectives:
This study aimed to determine the incidence of CP and CT after TTP using serial echocardiographic imaging, assess the timeline of CP and CT development, and identify predictors of CP and CT.
Methods:
A single-center, prospective, observational study was conducted at a tertiary care hospital in North India from January 2015 through December 2019. A total of 641 consecutive patients undergoing TTP were studied. Serial echocardiographic evaluations were performed at multiple predefined time points: before and after TTP, after permanent heart rhythm device implantation, before TTP electrode removal, after TTP electrode removal, and before discharge. Patients with preexisting pericardial effusion or those requiring cardiopulmonary resuscitation were excluded. Univariate and multivariate Cox regression analyses were performed to determine the predictors of CP and CT.
Results:
CP was observed in 59 (9.2%) patients. Small, moderate, and large effusions were observed in 33 (5.1%), 18 (2.8%), and 8 (1.2%) patients, respectively. Serial echocardiographic imaging detected new effusions in 3.7%, 1.1%, and 2.3% of patients after TTP electrode implantation, before temporary electrode removal, and after temporary electrode removal, respectively. Renal dysfunction and longer TTP duration were found to be significant predictors of CP.
Conclusion:
The use of serial echocardiographic imaging as a routine monitoring tool during TTP procedures enhances the early detection of CP and CT.
Related Concept Videos
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Pericarditis I: Introduction
Cardiac Catheterization II: Right Heart Catheterization
Pericarditis III: Medical Management
Pericarditis II: Clinical Features and Diagnostic Tests

