Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ultrasonography01:17

Ultrasonography

6.3K
Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vivo spatial coordination with synthetic paracrine signaling.

bioRxiv : the preprint server for biology·2026
Same author

3D Freehand Ultrasound Imaging of Optic Nerve Sheath.

Investigative radiology·2026
Same author

Ultrasound localisation microscopy tracks testicular microvascular adaptations to endocrine function in male infertility.

EBioMedicine·2026
Same author

Automatic Skull-Template Alignment Without a Guidance Image.

Ultrasound in medicine & biology·2026
Same author

Modulating Protein Function through Genetically Encoded Oxidative Chemistry.

Journal of the American Chemical Society·2026
Same author

Benchmarking Image-Based Motion-Correction Methods for Ultrasound Localization Microscopy.

Ultrasound in medicine & biology·2026

Related Experiment Video

Updated: Sep 17, 2025

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging
16:01

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging

Published on: September 24, 2017

10.6K

Enhanced Ultrasound Image Formation With Computationally Efficient Cross-Angular Delay Multiply and Sum Beamforming.

Cameron A B Smith1, Matthieu Toulemonde2, Marcelo Lerendegui3

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA; Department of Bioengineering, Imperial College London, London, UK.

Ultrasound in Medicine & Biology
|June 29, 2025
PubMed
Summary

A new ultrasound beamforming algorithm, Cross-Angular Delay Multiply and Sum (CADMAS), significantly improves image contrast. This advanced method enhances ultrasound imaging quality for various biological and clinical applications.

Keywords:
AMAcousticsB-ModeCADMASComputational efficiencyContrastDMASFMASGas vesiclesUltrafast imagingUltrasound

More Related Videos

Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator
08:39

Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator

Published on: January 28, 2019

9.9K
Blood Flow Imaging with Ultrafast Doppler
05:57

Blood Flow Imaging with Ultrafast Doppler

Published on: October 14, 2020

7.9K

Related Experiment Videos

Last Updated: Sep 17, 2025

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging
16:01

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging

Published on: September 24, 2017

10.6K
Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator
08:39

Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator

Published on: January 28, 2019

9.9K
Blood Flow Imaging with Ultrafast Doppler
05:57

Blood Flow Imaging with Ultrafast Doppler

Published on: October 14, 2020

7.9K

Area of Science:

  • Medical Imaging
  • Ultrasound Technology
  • Signal Processing

Background:

  • Conventional delay and sum (DAS) beamforming in ultrasound imaging has limitations in resolution and suffers from high side lobes.
  • Nonlinear processing techniques have emerged as effective methods for enhancing ultrasound image quality.

Purpose of the Study:

  • To introduce and evaluate a novel nonlinear beamforming algorithm, Cross-Angular Delay Multiply and Sum (CADMAS).
  • To assess the performance of CADMAS in improving image contrast and maintaining computational efficiency.

Main Methods:

  • CADMAS utilizes nonlinear compounding across plane-wave steering angles to enhance image contrast.
  • The algorithm was implemented with mathematical reformulation for low computational cost.
  • CADMAS was tested on B-Mode and amplitude modulation imaging, using in vitro and in vivo datasets with microbubbles and gas vesicles.
  • Comparisons were made against DAS, FMAS, DMAS, and combined nonlinear methods.

Main Results:

  • CADMAS demonstrated an average image contrast improvement of 7.6 to 40 dB over DAS and 4.8 to 20 dB over DMAS across datasets.
  • The computational time for CADMAS was found to be 1 to 2 times that of DAS, with a less than 6% increase in implementation.
  • Significant contrast enhancement was observed in both in vitro and in vivo imaging scenarios.

Conclusions:

  • CADMAS offers a robust improvement in image contrast for ultrasound imaging.
  • The algorithm shows potential for broad application in biological and clinical settings due to its effectiveness and efficiency.