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Updated: Sep 17, 2025

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
Published on: January 10, 2025
[Treatment of refractory chronic cough: current status and prospects]
L Zhang1, Aierken Alimire1, M R Zhang2
1Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Abstract:
Refractory chronic cough (RCC) poses significant clinical challenges due to its refractoriness and limited therapeutic efficacy, profoundly impacting patients' quality of life and mental health. Currently, cough hypersensitivity is recognized as a common and treatable trait in RCC patients. In terms of treatment, neuromodulators and novel receptor antagonists/agonists are the primary pharmacological interventions, with gabapentin being widely utilized and P2X3 receptor antagonists considered promising. However, despite advancements in antitussive drug development targeting neuronal hypersensitivity reduction, their efficacy remains modest, and the development of novel antitussive agents faces numerous challenges. Furthermore, the application of non-pharmacological therapies in RCC management is still in its nascent stage, necessitating further research and exploration. This review aims to synthesize the current treatment landscape of RCC and to forecast future therapeutic strategies and research fields.
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