Related Experiment Video
Updated: Sep 17, 2025
Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
Published on: August 13, 2015
Alcohol Intake-Induced Aggravation of Chronic Prostatitis/Chronic Pelvic Pain Syndrome is Associated with Reduced Gut
Chang Liu1,2,3, Shaoyu Yue1,2,3, Di Niu1,2,3
1Department of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.
Purpose:
Chronic prostatitis (CP) is a common urological disease and about 8.4% to 13.5% of men suffer from prostatitis symptoms in China. This study was conducted to evaluate the effect of alcohol usage on patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and the role of the gut microbiome in this course.
Materials And Methods:
A total of 151 individuals were recruited when they were diagnosed with CP/CPPS. Eventually, 38 patients were enrolled and grouped into three groups: the CP/CPPS group, alcohol group, and quitter group. 16S ribosomal ribonucleic acid sequencing was used to investigate the fecal samples, and a liquid chromatograph-mass spectrometer was used to analyze untargeted metabolomics. Next, targeted identification of short-chain fatty acids was carried out. T helper 17 (Th17) cells and cytokines were measured by flow cytometry and enzyme-linked immunosorbent assay, respectively. Furthermore, the associations among intestinal microbiota, short-chain fatty acids, and clinical symptoms were evaluated through correlation analysis.
Results:
Alcohol consumption results in different microbial composition in patients with CP. Higher symptom scores, Th17 cell percentages and interleukin-17 concentrations were observed in the alcohol group. Notably, correlation analysis revealed that several gut microbes were correlated with propionate and butyrate contents and patient's symptoms. Contrarily, lower symptom scores, Th17 cell percentages and interleukin-17 concentrations were observed in the quitter group.
Conclusions:
This study preliminarily explores the potential association between alcohol and CP/CPPS, in which short-chain fatty acid-producing gut flora may play a key role. This study may enhance the understanding of the effect of alcohol on CP/CPPS and provide a preliminary foundation for formulating prevention strategies. The main limitation of this study is the small sample size, and further large-scale plus in-depth research ought to be carried out in the future.
Related Concept Videos
01:17Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:27Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:21Drugs for Treatment of Constipation-Predominant IBS
01:30Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...