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Immunisation recommendations for children with single ventricle CHD

Sarah L Tallent1, Trudy A Pierick2, Jo Ann M Davis3

  • 1Division of Paediatric Cardiology, Duke University Medical Center, Durham, NC, USA.

Cardiology in the Young
|June 30, 2025
PubMed

Insights

Immunisation practices for children with single ventricle congenital heart disease (CHD) lack clear guidelines. Current practices show significant variability, with most centres delaying vaccinations around cardiopulmonary bypass.

Area of Science:

  • Pediatric Cardiology
  • Immunology
  • Public Health

Background:

  • Children with single ventricle congenital heart disease (CHD) have unique immunisation needs.
  • Current guidelines for vaccinating this population are insufficient, leading to inconsistent practices.

Purpose of the Study:

  • To investigate current immunisation practices in children with single ventricle CHD across various heart centres.
  • To identify variability and gaps in existing immunisation protocols for this vulnerable group.

Main Methods:

  • A survey was distributed to 53 heart centres to assess their immunisation recommendations for children with single ventricle CHD.
  • Responses from 40 centres (33 complete, 7 partial) were analyzed to understand current protocols and practices.

Main Results:

  • Significant variability exists in immunisation recommendations among surveyed centres.
  • Only 11% of centres reported having a written protocol for immunisation in these children.
  • Most centres (94% before, 97% after cardiopulmonary bypass) delay immunisations, and 34% re-dose vaccines post-bypass.

Conclusions:

  • There is a critical need for standardized guidelines for immunisation practices in children with single ventricle CHD.
  • Current practices are inconsistent, highlighting the need for further research to develop evidence-based recommendations.

Keywords:
Immunisationcardiopulmonary bypasssingle ventricle

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