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Analyzing the association between MPO levels and glaucoma severity

Lingling Chen1, Jinxia Wang2, Yanping Gao3

  • 1Department of Immunology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China.

Biomarkers in Medicine
|June 30, 2025
PubMed
Abstract

Insights

Elevated plasma myeloperoxidase (MPO) is linked to glaucoma. This biomarker may help understand glaucoma

Area of Science:

  • Ophthalmology
  • Biochemistry
  • Clinical Research

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Understanding biomarkers for glaucoma diagnosis and progression is crucial.
  • Myeloperoxidase (MPO) is an enzyme implicated in inflammatory processes.

Purpose of the Study:

  • To investigate the association between plasma myeloperoxidase (MPO) levels and glaucoma.
  • To assess the potential clinical utility of plasma MPO as a biomarker in glaucoma.

Main Methods:

  • A cross-sectional study included 127 glaucoma patients and 106 healthy controls.
  • Plasma MPO levels were measured using enzyme-linked immunosorbent assay (ELISA).
  • Statistical analyses were performed to compare MPO levels and correlate them with glaucoma severity and clinical parameters.

Main Results:

  • Glaucoma patients exhibited significantly higher plasma MPO levels compared to healthy controls (p < 0.001).
  • Plasma MPO remained an independent risk factor for glaucoma after adjusting for confounders (OR = 1.05, p < 0.001).
  • Elevated MPO levels were associated with glaucoma severity and higher cup-to-disc ratios, particularly in early versus severe stages (AUC = 0.633).

Conclusions:

  • Elevated plasma MPO levels are independently associated with an increased risk of glaucoma.
  • Plasma MPO may serve as a valuable biomarker for understanding glaucoma pathogenesis and potentially aiding in disease assessment.
Keywords:
Plasma myeloperoxidasedisease severityglaucomainflammationoxidative stress

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