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Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: Sep 17, 2025

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

Reducing NMDA Receptor Function Impacting Learning and Electroencephalogram Oscillations

Tyler D Dexter¹, Jared W Young^1,2

¹Department of Psychiatry, University of California San Diego, La Jolla, San Diego, California.

Biological Psychiatry Global Open Science

|June 30, 2025

Summary

No abstract available in PubMed .

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