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Updated: Sep 17, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Development and characterization of vitamin C- vitamin E co-loaded microcapsules: Storage stability, antioxidant
Ting Hu1, Jianhong Zhang1,2, Yingmei Wu1
1School of Public Health, The key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Province Engineering Research Center of Health Food Innovative Manufacturing, Guizhou Medical University, Guiyang 561113, China.
Abstract:
The inherent instability and poor bioavailability of vitamin C (VC) and vitamin E (VE) significantly limit their applications in food systems. In this study, a novel microcapsule through Wgel/O/W2 multiple emulsion template was developed by incorporating VC in a gelatin-based hydrogel inner phase (Wgel), VE in the oil phase (O), and maltodextrin-whey protein isolate (MD-WPI) composite as the outer water phase (W2), followed by freeze-drying. Optimized microcapsules (MD:WPI = 1:4, 0.10 wt% VC and VE) exhibited superior encapsulation efficiency (91.86 % for VC, 88.33 % for VE). Storage stability studies showed that aluminum foil-sealed packaging at 4 °C provided optimal protection, with 3.35-fold and 1.56-fold extended half-lives for VC and VE respectively. The co-loaded microcapsules exhibited enhanced DPPH radical scavenging capacity (98.56 %) and demonstrated controlled release behavior, with bioavailability increased by 2.51-fold and 2.28-fold for VC and VE respectively. This microencapsulation strategy offers promising potential for dual-vitamin delivery in functional food applications.
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