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Updated: Sep 17, 2025

Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System
Published on: March 18, 2010
Yeast gene of unknown function YGL081W is involved in DNA damage response
Ari King1, Taylor M Emery1, Katie Reese1
1Department of Biology, Chemistry, Mathematics, and Computer Science, University of Montevallo, Montevallo, Alabama, United States.
Abstract:
This study aimed to better characterize gene of unknown function YGL081W in Saccharomyces cerevisiae. Bioinformatic analysis revealed that YGL081W possesses a forkhead associated (FHA) domain, known to be involved in DNA repair and cell cycle arrest. Furthermore, YGL081W was predicted to interact with genes involved in cell cycle regulation and its expression changed during mitotic stress. YGL081W knockout cells grew modestly better than wild type under normal growth conditions, grew significantly less than wild type when exposed to UV light, and grew no differently than wild type in the presence of hydroxyurea. Collectively, these data suggest YGL081W is involved in mediating the DNA damage response in S. cerevisiae.
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