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Psychoneuroimmunology: Cardiovascular Disease01:27

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Related Experiment Video

Updated: Sep 17, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Psoriasis: an emerging risk factor for ischemic stroke?

Piotr Olejnik1, Kaja Kasarełło2, Renata Podkowińska-Polak3

  • 1Department of Neurology, Medical University of Warsaw, Warsaw, Poland.

Frontiers in Neurology
|June 30, 2025
PubMed
Summary

Psoriasis, an autoimmune disease causing systemic inflammation, significantly increases the risk of acute ischemic stroke (AIS). Understanding this link is crucial for preventing strokes in affected individuals.

Keywords:
acute ischemic strokeautoimmune erythematous-squamous diseasepsoriasissystemic inflammationtraditional cardiovascular risk factors

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Area of Science:

  • Dermatology
  • Neurology
  • Cardiology

Background:

  • Psoriasis is a chronic autoimmune disease with systemic inflammatory effects.
  • Psoriasis is linked to a higher incidence of acute ischemic stroke (AIS).
  • Patients with psoriasis exhibit increased prevalence of traditional cardiovascular risk factors.

Purpose of the Study:

  • To review the scientific literature on the association between psoriasis and AIS.
  • To provide a comprehensive overview of current understanding.
  • To highlight the importance of non-traditional risk factors in stroke prevention.

Main Methods:

  • Narrative review of existing scientific literature.
  • Synthesis of research on psoriasis, systemic inflammation, and AIS.
  • Analysis of potential mechanisms linking psoriasis to stroke.

Main Results:

  • Psoriasis patients face a heightened risk of stroke, with severity correlating to increased risk (up to 44%).
  • Chronic systemic inflammation in psoriasis may contribute to endothelial dysfunction and atherosclerosis.
  • Metabolic syndrome is more prevalent in psoriasis patients, a known cardiovascular risk factor.

Conclusions:

  • The association between psoriasis and AIS is supported by evidence of systemic inflammation and shared risk factors.
  • Further research into non-traditional risk factors like psoriasis is vital for primary stroke prevention.
  • Recognizing psoriasis as a risk factor for AIS is essential for public health strategies.