Structurally and Functionally Adaptive Biomimetic Periosteum: Materials, Fabrication, and Construction Strategies

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Orthopedic Surgery

Background:

• The periosteum is vital for bone formation, regeneration, and remodeling.
• Periosteal progenitor cells are key initiators of bone healing.
• Bone defects require effective treatment strategies for regeneration.

Purpose of the Study:

• To review recent advancements in biomimetic periosteum (BP) for bone defect repair.
• To analyze the structure, function, and biomimetic design of BP.
• To summarize construction strategies and materials for effective BP development.

Main Methods:

• Literature review of recent research on biomimetic periosteum.
• Analysis of studies focusing on BP structure, function, and biomimicry.
• Overview of materials and techniques used in BP construction.

Main Results:

• Biomimetic periosteum (BP) shows superior outcomes in bone integrity and vascularization.
• BP minimizes heterotopic ossification compared to conventional bone void fillers.
• BP requires excellent biocompatibility and mechanical properties for in vivo application.

Conclusions:

• BP is a contemporary and effective approach for treating bone defects.
• Future development of BP should focus on structural and functional biomimicry.
• Continued research is essential for optimizing BP for bone regeneration.