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Updated: Sep 17, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Intussusception of the Left Atrial Appendage: A Systematic Review.

Riccardo Scagliola1, Giancarlo Passerone2, Manrico Balbi3

  • 1Cardiology Division, Cardinal G. Massaia Hospital, Asti, Italy.

CJC Open
|June 30, 2025
PubMed
Summary

Left atrial appendage (LAA) intussusception is a rare condition often missed in clinical practice. This systematic review highlights its characteristics and management, emphasizing the need for physician awareness to ensure accurate diagnosis and treatment.

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Surgical Pathology

Background:

  • Left atrial appendage (LAA) intussusception is an uncommon condition with limited awareness in clinical settings.
  • Existing knowledge gaps necessitate a comprehensive overview of LAA intussusception.

Purpose of the Study:

  • To provide a comprehensive and updated systematic review of left atrial appendage intussusception.
  • To consolidate current knowledge on the demographics, diagnosis, and management of LAA intussusception.

Main Methods:

  • A systematic literature search was conducted across major scientific databases.
  • Twenty-five case reports involving adult patients diagnosed with LAA intussusception were included.

Main Results:

  • The median age of affected patients was 54 years, with a slight female predominance (53%).
  • Diagnosis was often intraoperative (60%) or incidental via imaging (20%).
  • Transesophageal echocardiography was commonly used; intervention resolved most cases (60%).

Conclusions:

  • This systematic review represents the largest to date on adult LAA intussusception.
  • Physicians must recognize LAA intussusception to prevent misdiagnosis and guide appropriate management.
  • Increased awareness is crucial for timely recognition and effective treatment of this rare condition.