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Patch Clamp01:18

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Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
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Seasonal Trends in Patch Testing: A Large Single-Center Retrospective Cohort Study.

Zvi Segal1, Sharon Baum1, Aviv Barzilai1

  • 1Department of Dermatology, Sheba Medical Center, Tel Hashomer, Israel, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.

The Israel Medical Association Journal : IMAJ
|June 30, 2025
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Summary
This summary is machine-generated.

Patch testing for allergic contact dermatitis (ACD) showed no difference in positive results between summer and winter. This indicates that reliable ACD diagnosis is possible year-round, even during warmer months.

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Area of Science:

  • Dermatology
  • Allergology
  • Clinical Immunology

Background:

  • Allergic contact dermatitis (ACD) is a common skin condition diagnosed via patch testing.
  • Previous research suggested seasonal variations in patch test positivity, with lower rates in summer.
  • Understanding these variations is crucial for accurate ACD diagnosis.

Purpose of the Study:

  • To determine if there is a significant difference in positive patch test results between summer and winter months.
  • To evaluate the reliability of patch testing during different seasons.

Main Methods:

  • A retrospective analysis of 1142 patch tests from 1128 patients conducted between 2016 and 2020.
  • Data included patient demographics and patch test outcomes.
  • Tests utilized standard series like European, cosmetics, and fragrances.

Main Results:

  • Overall, 70.8% of patch tests were positive.
  • No statistically significant difference in positive patch test proportions was found between summer (74.7%) and winter (71.4%).
  • Seasonal testing rates for most series were similar, except for fragrances.

Conclusions:

  • Patch testing for allergic contact dermatitis is reliable regardless of season.
  • Summer patch testing does not increase the risk of false-negative results.
  • Dermatologists can confidently perform patch tests year-round.