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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Aptamer-based biosensors for tobramycin.

Jizhao Zhang^1,2,3, Qiang Zhao^1,2,3

¹School of Environment, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China.

Analytical Methods : Advancing Methods and Applications

|June 30, 2025

Summary

This summary is machine-generated.

Rapid detection of tobramycin is crucial due to environmental and health risks. Aptamer-based biosensors offer a promising solution for sensitive and selective tobramycin detection in various applications.

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Area of Science:

Biomedical Engineering
Analytical Chemistry
Environmental Science

Background:

Widespread tobramycin use leads to environmental contamination and health concerns.
Accurate and swift detection methods for tobramycin are urgently needed.
Aptamers offer high specificity and affinity for target molecules like tobramycin.

Purpose of the Study:

To review the selection and characterization of DNA and RNA aptamers for tobramycin.
To summarize recent advancements in aptamer-based biosensors for tobramycin detection.
To analyze the principles, applications, advantages, and limitations of these biosensors.

Main Methods:

Selection of DNA and RNA aptamers against tobramycin.
Development and characterization of aptamer-based biosensors (electrochemical, colorimetric, fluorescence).
Review of existing literature on aptamer-based tobramycin detection.

Main Results:

Aptamers have been successfully selected for tobramycin recognition.
Various aptamer-based biosensors demonstrate high sensitivity and selectivity.
Different sensor platforms offer diverse detection capabilities and performance metrics.

Conclusions:

Aptamer-based biosensors are effective tools for tobramycin detection.
These biosensors hold significant potential for environmental monitoring and medical diagnostics.
Further research can optimize sensor performance and expand application scope.