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Action-mode subnetworks for decision-making, action control, and feedback.

Carolina Badke D'Andrea1,2,3, Timothy O Laumann2, Dillan J Newbold4

  • 1Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110.

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|June 30, 2025
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Summary
This summary is machine-generated.

The action-mode network (AMN) has distinct subnetworks for decision-making, action execution, and feedback processing. This research precisely maps individual AMN structure to understand goal-directed behavior and self-perception.

Keywords:
action controlaction-mode networkcognitive controlfunctional connectivityprecision functional mapping

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Functional Neuroimaging

Background:

  • The action-mode network (AMN) is a key brain network involved in goal-directed behavior.
  • Previous group-averaged fMRI studies created ambiguity regarding specific AMN functions.
  • An inside-out approach is needed to precisely map individual AMN architecture.

Purpose of the Study:

  • To precisely map individual-specific AMN subnetworks using high-resolution functional connectivity and task fMRI data.
  • To associate these precisely mapped subnetworks with specific behavioral functions.
  • To elucidate the role of the AMN in decision-making, action execution, feedback processing, and self-perception.

Main Methods:

  • Utilized >5 hours of resting-state functional connectivity (RSFC) and task fMRI data for individual-specific mapping.
  • Employed a meta-analytic network association method for subnetwork characterization.
  • Integrated RSFC, intrinsic timing, and task activation profiling to annotate AMN subnetworks.

Main Results:

  • Identified a replicable, individual-specific AMN subnetwork structure.
  • Demonstrated the existence of AMN-Decision, AMN-Action, and AMN-Feedback subnetworks.
  • Revealed a temporally sequential processing stream supporting goal adjudication, action planning, and feedback modification.
  • Discovered a distinct cingulate subnetwork potentially involved in bodily self-construction.

Conclusions:

  • Individual-specific mapping refines understanding of the AMN's role in goal-directed behavior.
  • The AMN comprises distinct, sequentially organized subnetworks for decision, action, and feedback.
  • The AMN plays a crucial role in adaptive behavior and may contribute to the sense of self.