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Related Experiment Video

Updated: Jun 23, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

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Functional brain organization is stable within individuals across years.

Hyejin J Lee, Ally Dworetsky, Alexis Porter

Biorxiv : the Preprint Server for Biology

|June 22, 2026

Summary

Brain functional networks are remarkably stable over time, showing individual-specific organization preserved for up to 13 years. This suggests brain architecture reflects enduring personal identity, supported by homeostatic mechanisms.

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Last Updated: Jun 23, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

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Published on: May 7, 2014

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Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

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Published on: March 21, 2019

Area of Science:

Neuroscience
Human Brain Imaging
Functional Connectivity

Background:

Brain activity forms large-scale functional networks, measurable via resting-state correlations.
While often seen as dynamic, these networks may be person-specific and stable over time.

Purpose of the Study:

To investigate the long-term stability of individual functional brain networks.
To determine if functional network organization persists across years.

Main Methods:

Longitudinal precision functional MRI (fMRI) data collected from healthy young adults over 1-13 years.
Replication using the MyConnectome dataset with a 10-year follow-up.

Main Results:

Individual functional brain network organization remained stable over prolonged periods (up to 13 years).
Sufficient per-participant data revealed persistent, unique characteristics of brain organization within individuals.

Conclusions:

The healthy young adult brain's functional organization is preserved long-term, exhibiting stable, individual characteristics.
This stability suggests brain architecture encodes persistent features of personal identity, potentially maintained by homeostatic mechanisms.
Findings offer insights into brain resilience, plasticity, and markers of healthy brain function.