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Related Experiment Videos

Clostridium difficile colitis associated with single-dose cefazolin prophylaxis.

S G McNeeley, G D Anderson, B M Sibai

    Obstetrics and Gynecology
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    Clostridium difficile colitis can occur even after a single dose of cefazolin prophylaxis during cesarean section. Oral vancomycin effectively treated this serious adverse event, highlighting the importance of prompt diagnosis and management.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Gastroenterology

    Background:

    • Antimicrobial agents, including cephalosporins like cefazolin, are frequently used for surgical prophylaxis.
    • Antibiotic-associated diarrhea and Clostridium difficile infection (CDI) are known complications of antimicrobial therapy.

    Observation:

    • A patient developed Clostridium difficile colitis following a single prophylactic dose of cefazolin administered during a cesarean section.
    • The patient presented with symptoms indicative of severe gastrointestinal distress.

    Findings:

    • The diagnosis of Clostridium difficile colitis was confirmed in the patient.
    • Treatment with oral vancomycin led to a rapid and complete remission of symptoms.

    Implications:

    Related Experiment Videos

    • This case underscores the potential risk of CDI even with short-term, single-dose antibiotic prophylaxis.
    • Early recognition and appropriate treatment, such as with oral vancomycin, are crucial for managing antibiotic-associated Clostridium difficile colitis.
    • Clinicians should maintain a high index of suspicion for CDI in patients presenting with diarrhea post-antimicrobial exposure, regardless of duration.