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A Study on Regulating OSCC Cell Function by Blocking Integrin αvβ3 With Cilengitide.

Liujun Zeng1,2,3, Huanquan Nie1,2,3, Haofeng Xiong1,2,3

  • 1Department of Oral and Maxillofacial Surgery, Centre of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|July 1, 2025
PubMed
Summary
This summary is machine-generated.

Integrin αvβ3 is upregulated in oral squamous cell carcinoma (OSCC). Inhibiting this integrin suppresses OSCC cell proliferation, migration, and invasion, offering a potential therapeutic target for oral cancer.

Keywords:
ITGAVITGB3Oral squamous cell carcinomaintegrin αvβ3proliferation

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Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Medicine

Background:

  • Oral squamous cell carcinoma (OSCC) is a prevalent oral malignancy.
  • Integrin-mediated processes are crucial in cancer progression.
  • Integrin αvβ3 plays roles in tumor cells beyond angiogenesis.

Purpose of the Study:

  • To investigate the function of tumor cell integrin αvβ3 in OSCC progression.
  • To explore the impact of integrin αvβ3 on OSCC cell behaviors.

Main Methods:

  • Immunohistochemistry to assess integrin αvβ3 expression in OSCC tissues.
  • In vitro assays (CCK-8, EdU, cell cycle, scratch, Transwell, adhesion, colony formation, apoptosis) to evaluate OSCC cell behaviors.
  • In vivo experiments to validate findings.

Main Results:

  • Integrin αvβ3 expression is elevated in OSCC.
  • Inhibition of integrin αvβ3 using cilengitide reduced OSCC cell proliferation, adhesion, migration, and invasion.
  • Integrin αvβ3 affects the cell cycle, influencing proliferation.

Conclusions:

  • Integrin αvβ3 is upregulated in OSCC and promotes tumor progression.
  • Targeting integrin αvβ3 inhibits OSCC cell proliferation, migration, and invasion both in vitro and in vivo.
  • Integrin αvβ3 represents a potential therapeutic target for OSCC.