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Infected pericardial effusion caused by Prevotella intermedia: a rare diagnosis

Wan Xu1, Dan Han2, Tianyang Chen2

  • 1Songnan Community Health Service Center, Shanghai, China.

Frontiers in Cellular and Infection Microbiology
|July 1, 2025
PubMed

Insights

Prevotella intermedia, a challenging bacterium, was detected in pericardial effusion using metagenomic next-generation sequencing. This advance offers crucial early detection and clinical guidance for this pathogen in China.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genomics

Background:

  • Prevotella intermedia is an anaerobic Gram-negative bacterium.
  • Standard laboratory methods face challenges in detecting Prevotella intermedia.
  • No prior reports exist of Prevotella intermedia detection in pericardial effusion within China.

Purpose of the Study:

  • To investigate the utility of Metagenomic Next-Generation Sequencing (mNGS) for detecting Prevotella intermedia in pericardial effusion.
  • To establish the first documented instance of Prevotella intermedia in Chinese pericardial effusion cases.
  • To explore the potential of mNGS in guiding early clinical management.

Main Methods:

  • Utilized Metagenomic Next-Generation Sequencing (mNGS) on pericardial effusion samples.
  • Employed advanced bioinformatics analysis for pathogen identification.
  • Compared mNGS results with conventional diagnostic methods (implicitly).

Main Results:

  • Successfully detected Prevotella intermedia in pericardial effusion using mNGS.
  • Established the first documented case of Prevotella intermedia in pericardial effusion in China.
  • mNGS demonstrated a higher detection rate for this pathogen compared to routine assays.

Conclusions:

  • Metagenomic Next-Generation Sequencing is a powerful tool for detecting challenging pathogens like Prevotella intermedia.
  • This study establishes a new precedent for Prevotella intermedia detection in pericardial effusion in China.
  • Early detection via mNGS can significantly improve clinical management strategies for related infections.
Keywords:
Prevotella intermediainfectionmNGspericardial effusionpericardial tamponade

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