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Updated: Sep 17, 2025

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
Evaluation of Metastatic Insulinoma With Severe Hypoglycemia Using 68 Ga-Exendin-4 PET/CT
Jing Gao1,2,3,4,5,6, Junyan Xu1,2,3,4,5,6, Yun Liang7
1Department of Nuclear Medicine, Fudan University Shanghai Cancer Center.
Abstract:
A 52-year-old man was pathologically diagnosed with a pancreatic neuroendocrine tumor (pNET) and synchronous liver metastasis through debulking surgery 2 years ago. Recently, the patient showed recurrent severe hypoglycemia after receiving multiple treatments. 68 Ga-Exendin-4 PET/CT imaging revealed diffuse uptake in the skeleton and other metastatic sites, which 68 Ga-DOTANOC PET/CT grossly underestimated. This case highlights the crucial role of 68 Ga-Exendin-4 in the comprehensive and accurate evaluation of metastatic insulinomas.
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