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Positron Emission Tomography01:29

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Related Experiment Video

Updated: Sep 17, 2025

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
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18F-FDG dose reduction using deep learning-based PET reconstruction.

Ryuji Akita1, Komei Takauchi2, Mana Ishibashi3

  • 1Department of Diagnostic Radiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. akita13@hiroshima-u.ac.jp.

EJNMMI Research
|July 1, 2025
PubMed
Summary
This summary is machine-generated.

Deep learning-based image reconstruction (DLR) can reduce 18F-FDG doses in PET/CT scans. This study shows DLR allows a 36% dose reduction in patients under 75kg while maintaining diagnostic quality.

Keywords:
18F-FDGDeep learning-based reconstructionDose reductionImage qualityPET/CT

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Area of Science:

  • Nuclear Medicine
  • Medical Imaging
  • Radiology

Background:

  • A deep learning-based image reconstruction (DLR) algorithm has been developed for PET/CT imaging to reduce statistical noise.
  • DLR may allow for reduced 18F-FDG doses, minimizing radiation exposure while maintaining diagnostic quality.

Purpose of the Study:

  • To evaluate if DLR can reduce the injected 18F-FDG dose in PET/CT imaging.
  • To compare quantitative image quality metrics and false-positive rates between DLR with reduced dose and OSEM with standard dose.

Main Methods:

  • Retrospective study of 90 oncology patients undergoing 18F-FDG PET/CT.
  • Patients divided into three groups: Group A (2.00-2.99 MBq/kg, DLR), Group B (3.00-3.99 MBq/kg, DLR), and Group C (4.00-4.99 MBq/kg, OSEM).
  • Evaluation using signal-to-noise ratio (SNR), target-to-background ratio (TBR), and false-positive rate.

Main Results:

  • DLR significantly increased SNRs in Groups A and B compared to Group C (p < 0.001).
  • No significant difference in TBR between DLR groups (A, B) and OSEM group (C).
  • In Group B, over 80% of patients <75kg had ≤1 false positive; patients ≥75kg and Group A had <80% with ≤1 false positive.

Conclusions:

  • The injected 18F-FDG dose can be reduced to 3.0 MBq/kg with DLR in patients <75kg, a 36% reduction from EANM guidelines.
  • Further DLR algorithm optimization is needed for comparable diagnostic accuracy in patients ≥75kg.