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Updated: Sep 17, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
The HNRNPs and neurodevelopmental disorders
1HNRNP Family Foundation, Seattle, WA, USA.
Abstract:
The HNRNP gene family has long been investigated in neurodegenerative disorders and cancer. Over the last several years, multiple members of the gene family have been associated with neurodevelopmental disorders. To date, there are nine well-established HNRNP-related neurodevelopmental disorders (HNRNP-RNDDs), at least three that are actively being characterized, and several candidate genes with a small number of patients. Here, we review the over 1000 individuals in the literature and patient databases and describe the overall phenotypic spectra of the HNRNP-RNDDs. Furthermore, we discuss recent advances in understanding the pathomechanisms of the HNRNP-RNDDs and how that will impact future therapeutic development.
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