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[Relationship between internal exposure levels and age and abnormal liver function in dimethylformamide exposed
1Department of Occupational Health, Taicang Center for Disease Control and Prevention, Taicang 215400, China.
Summary
Dimethylformamide (DMF) exposure and worker age are linked to abnormal liver function. Gamma-glutamyl transpeptidase (γ-GT) is a sensitive marker, and elderly workers require attention for alanine aminotransferase (ALT) changes.
Area of Science:
- Occupational health
- Toxicology
- Biomonitoring
Context:
- Dimethylformamide (DMF) is widely used in synthetic leather production.
- Occupational exposure to DMF can lead to adverse health effects, particularly liver dysfunction.
- Monitoring internal DMF exposure is crucial for worker health surveillance.
Purpose:
- To investigate the association between internal DMF exposure, measured by N-methylcarbyl hemoglobin adduct (NMHb), and abnormal liver function indicators.
- To explore the influence of worker age as a factor in DMF-induced liver toxicity.
- To provide data for the prevention of DMF-related occupational diseases.
Summary:
- A study of 388 synthetic leather workers found that both NMHb levels and age were significant factors in abnormal liver function.
- While no significant interaction was found between NMHb and age, NMHb correlated positively with abnormal liver function markers like ALT, AST, and γ-GT.
- Age showed complex correlations, negatively impacting ALT abnormality risk but positively influencing AST/ALT ratios.
Impact:
- γ-GT is identified as a sensitive biomarker for DMF-induced liver dysfunction.
- Elderly workers exposed to DMF require specific monitoring for ALT levels.
- Age should be considered when using AST/ALT as a screening tool for liver abnormalities in DMF-exposed populations.
