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Updated: Sep 17, 2025

Establishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip
Published on: September 27, 2019
Integration of multiple coinflip devices for high-quality random sampling
Brady Taylor1,2, J Darby Smith3, Shashank Misra3
1Sandia National Laboratories, Albuquerque, NM, 87123, USA. btaylor@sandia.gov.
None:
Artificial intelligence, scientific computing, and probabilistic computing use random sampling to approximate solutions to various problems, with larger models requiring a substantial quantity of random numbers. To generate the required vast quantity of random numbers at high rates, we explore so-called "coinflip" devices, which are stochastic microelectronic devices ideally capable of independently generating random bits with a tunable weight at a high rate. However, coinflip devices are inherently analog and demonstrate nonidealities, like temperature dependence and drift, that can introduce determinism into the outputs. We present important considerations for building systems of multiple coinflip devices to produce high-quality bitstreams with low error and little dependency on previous bits. Using tunnel diodes as coinflip devices, we implement a control loop to adapt to temperature dependence and generate fair bitstreams with each device. While this can lead to dependencies between bits in a single bitstream, we demonstrate that combining results generated in parallel with individual tunnel diodes can produce fair and unpredictable bitstreams. The suitability of these bitstreams for use in probabilistic computing is then demonstrated through a Monte Carlo approximation of π.
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