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The interplay between endoplasmic reticulum stress and inflammation in multiple sclerosis
Zhila Maghbooli1, Forough Azam Sayahpour2, Tarlan Varzandi3,4
1Multiple Sclerosis Research Center, Neurosciences Institute, Tehran University of Medical Sciences, Tehran, Iran. zhilayas@gmail.com.
Scientific Reports
|July 2, 2025
Summary
Endoplasmic reticulum (ER) stress marker GRP78 is upregulated in multiple sclerosis (MS) patients. The interaction between GRP78 and tumor necrosis factor-alpha (TNF-α) influences MS risk, suggesting a role in disease modulation.
Area of Science:
- Neuroscience
- Immunology
- Cell Biology
Background:
- Endoplasmic reticulum (ER) stress is a key feature of neurodegenerative diseases.
- Understanding ER stress and inflammation in multiple sclerosis (MS) is crucial.
Purpose of the Study:
- To investigate the interplay between ER stress markers and inflammatory markers in MS patients.
- To determine the association of ER stress and inflammation with MS risk.
Main Methods:
- Compared gene expression of ER stress markers (CHOP, GRP78) and serum levels of inflammatory cytokines (IL-1β, TNF-α) in MS patients and controls.
- Analyzed the interaction between GRP78 and TNF-α in relation to MS risk.
Main Results:
- Serum TNF-α levels were significantly elevated in MS patients compared to controls.
- GRP78 expression was significantly upregulated in MS patients.
- No significant changes were observed in CHOP expression or IL-1β levels.
Conclusions:
- The interaction between GRP78 and TNF-α significantly influences the risk of developing MS.
- These findings suggest that the interplay between GRP78 and TNF-α may modulate ER stress in the context of MS.
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