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Lactylation associated biomarkers and immune infiltration in aortic dissection
Jianfeng Ye1,2, Yuntao Fu3, Yuanjia Ke3
1Department of Cardiology, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, 523326, Guangdong, China.
Scientific Reports
|July 2, 2025
Summary
Protein lactylation plays a key role in aortic dissection (AD). Researchers identified PGK1 and HMGA1 as crucial lactylation-related genes, offering potential new biomarkers for AD diagnosis and treatment.
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Background:
- Protein lactylation is a novel post-translational modification impacting glycolysis and immune responses.
- Its specific role in aortic dissection (AD) pathogenesis remains largely unexplored.
Purpose of the Study:
- To investigate the involvement of protein lactylation in AD.
- To identify key lactylation-related genes as potential diagnostic biomarkers for AD.
Main Methods:
- Analysis of public transcriptomic data to find differentially expressed lactylation-related genes.
- Weighted Gene Co-expression Network Analysis (WGCNA) and machine learning (LASSO, Random Forest) for biomarker identification.
- Experimental validation in human and murine AD tissues.
Main Results:
- Identified 11 lactylation-related differentially expressed genes (LR-DEGs) in AD.
- PGK1 and HMGA1 were identified as optimal diagnostic genes with high accuracy (AUCs of 1 and 0.94, respectively).
- These genes correlated with immune cell infiltration, suggesting a role in immune regulation.
Conclusions:
- Protein lactylation is important in AD pathogenesis.
- PGK1 and HMGA1 are key lactylation-related biomarkers for AD.
- Findings provide insights into AD's metabolic and immune mechanisms, suggesting new diagnostic and therapeutic targets.
