Targeted Therapeutic Approach Employing In Silico Methods to Identify Potent Flavonoids in Cervical Cancer

The prevalence of cervical cancer has substantially increased, leading to global apprehension. The signaling pathway governs many cellular differentiation processes that occur during embryonic development and adulthood.

Our study has mostly focused on discovering inhibitory plant chemicals, specifically flavonoids, that can block the Notch signaling pathway owing to the numerous adverse effects associated with standard treatments. Thus far, only a few studies have documented these specific flavonoids' ability to inhibit the three essential targets of the Notch signaling system in cervical cancer.

This study aimed to assess the inhibitory potential of twenty-five potent flavonoids against the Notch signaling pathway components in cervical cancer using various in silico methods.

Of all the compounds tested, naringenin exhibited the most favorable binding energy (with concrete free binding energy value) against jagged2, notch 2, and notch 3 in cervical cancer.

Naringenin has been reported with significant anticancer potential in several carcinomas and hence we have selected for its evaluation against cervical cancer. Amongst all, naringenin has shown significant anticancer potential. However, significant amount of experiments including clinical studies are needed to validate its candidature for cervical cancer.

Naringenin could further be evaluated for its anticancer potential in cervical cancer via employing in vitro approaches. To overcome the limitations of current chemotherapeutic procedures, developing naringenin as a novel anticancer drug requires a systematic and strategic approach to rational drug discovery that is both efficient and cost-effective.