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Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
Time-Frequency Fingerprint Analysis in SEEG Source-Space to Identify the Epileptogenic Zone
Yash Shashank Vakilna1, Deniz Atilgan1, Johnson Hampson1
1Texas Institute for Restorative Neurotechnologies (TIRN), Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
None:
This case study highlights the application of seizure fingerprint analysis in the source-space of stereo-EEG (SEEG) data to accurately localize the epileptogenic zone (EZ) in patients with complex cortical malformations. A 25-year-old female with extensive bilateral perisylvian polymicrogyria (PMG) presented with intractable focal seizures. The source-level analysis performed in Brainstorm using the sLORETA imaging algorithm subsequently showed EZ fingerprint analysis. The patient underwent MR-guided laser interstitial thermal therapy (LITT), targeting the identified EZ, resulting in postoperative seizure freedom with minimal complications. Extending the analysis from the sensor-space to the source-space could further enhance surgical planning and improve outcomes in complex epilepsy cases.
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