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Updated: Sep 17, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Dimorpoloids A-D, Three Rearranged Diterpenoids and One Unique Daphnane-Type Diterpenoid from Dimorphocalyx poilanei
Shu-Shuai Chen1,2, Yu-Han Chen2, Cheng-Yu Zheng1
1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
None:
The first phytochemical investigation of Dimorphocalyx poilanei led to the isolation and characterization of four novel diterpenoids, namely, dimorpoloids A-D (1-4), along with two biosynthetically related known diterpenoids. Compounds 1 and 2 are rearranged ent-cleistanthane diterpenoids with a 6/7/6-fused tricyclic scaffold. Compound 3 is a rearranged 17-nor-ent-labdane-type diterpenoid, distinguished by a novel tropone ring system in its molecular architecture. Compound 4 represents the first daphnane-type diterpenoid featuring an aromatic C-ring system. Their structures were elucidated by spectroscopic analysis and quantum chemical calculations. Putative biosynthetic pathways for compounds 1-3 are proposed. Compounds 1 and 3-6 exhibited antiadipogenic effects in 3T3-L1 adipocytes, and the most potent compound 6 showed an EC50 value of 3.29 ± 0.53 μM.
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