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Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
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Unraveling Benign Breast Conditions: A Comprehensive Study of Diagnosis, Treatment, and Care
Priya Ahire1, Pooja Nagwani2, Rukmini Waghmare1
1General Surgery, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, IND.
Abstract:
Introduction The breast undergoes cyclical changes influenced by hormones, with benign breast diseases (BBDs) being more common than malignant conditions. These conditions can present with symptoms such as lumps, pain, swelling, and nipple discharge. This study investigates the incidence, clinical features, age distribution, and management of BBDs, providing insight into the common breast-related issues that affect women across different stages of life. Methodology A prospective observational study was conducted at a tertiary care hospital from August 2021 to December 2022, including 100 patients with breast-related complaints. Participants underwent detailed history, clinical examination, and relevant investigations such as ultrasonography, mammography, and fine needle aspiration cytology (FNAC). Data were analyzed using Excel and SPSS, with continuous variables presented as mean ± standard deviation and categorical data as numbers and percentages. Results In the present study, the mean age of the 100 participants with BBD was 34.98±11.97 years, with the majority (78/100, 78%) presenting with lumps. Fibroadenoma was the most common diagnosis, seen in 59/100 (59%), followed by fibroadenosis in 19/100 (19%) and breast abscess in 16/100 (16%). The mean age of menarche among patients with BBD was 14.52±1.80 years, with 56/100 (56%) attaining menarche between 13 and 15 years. Additionally, 81/100 (81%) were married, and 10/100 (10%) had a history of lactation. The majority of patients with BBD had lumps in the right upper outer quadrant, with most lumps being firm and mobile, and 97/100 (97%) showed no axillary lymph node involvement. Most patients were treated with excision, while others received conservative treatment with reassurance, analgesics, and antibiotics, with diagnosis confirmed through ultrasonography and mammography. Discussion The spectrum of BBDs in our study aligns with findings from other studies, with fibroadenoma being the most prevalent lesion, followed by fibrocystic changes. These conditions predominantly affect young women under the age of 40 in our population. Conclusion In conclusion, BBDs, particularly fibroadenoma, are common and require accurate clinical assessment, with FNAC being a reliable diagnostic tool. Early detection through breast self-examination and regular follow-ups, along with continued education on benign breast conditions, is essential for effective management and patient care.
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