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Mesenchymal and Biliary Hamartomas of the Liver: A Systematic Review and Management Algorithm
Kshiraj V Talati1, Christine M G Schammel2, A Michael Devane3
1Department of Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
The American Surgeon
|July 2, 2025
Summary
Mesenchymal hamartomas, rare liver tumors, can occur in adults. This study reviews mesenchymal and biliary hamartomas, proposing an algorithm to aid diagnosis and potentially avoid surgery for benign liver lesions.
Area of Science:
- Hepatology
- Pediatric Surgery
- Surgical Pathology
Background:
- Mesenchymal hamartomas are rare, benign liver tumors typically affecting infants and young children.
- Biliary hamartomas are distinct benign lesions more common in adults over 35.
- Both entities often present with nonspecific imaging findings, necessitating histologic evaluation.

