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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...

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Updated: Jun 27, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Occult Pulmonary Adenosquamous Carcinoma Presenting With Synchronous Colonic Metastases.

Mary Hunter Hyche1, Isabella Lopez2, Christine Marie-Gilligan Schammel2

  • 1Department of Health Sciences, University of South Carolina School of Medicine, Columbia, SC, USA.

The American Surgeon
|June 26, 2026
PubMed
Summary

Gastrointestinal metastases from lung cancer are rare, especially in the colon. This case highlights the challenges in diagnosing and treating lung adenocarcinoma with colonic spread, emphasizing comprehensive tissue analysis and multidisciplinary care for better outcomes.

Keywords:
adenosquamous carcinomacolonic metastasisimmunohistochemistryintratumoral heterogeneitylung adenocarcinomametastatic NSCLC

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Published on: March 12, 2018

Area of Science:

  • Oncology
  • Pulmonology
  • Gastroenterology

Background:

  • Gastrointestinal metastases from lung cancer are uncommon, with symptomatic colonic involvement being exceptionally rare.
  • Lung adenocarcinoma with colonic metastases presents unique diagnostic and prognostic challenges.

Purpose of the Study:

  • To present a rare case of lung adenocarcinoma with synchronous colonic metastases.
  • To highlight the diagnostic complexities and therapeutic strategies for this rare presentation.

Main Methods:

  • Case report of a 60-year-old female smoker with incidental discovery of endobronchial mass.
  • Immunohistochemical and molecular characterization of primary lung tumor and metastases.
  • Histology-guided treatment sequencing including chemoradiation, immunotherapy, and palliative surgery.

Main Results:

  • Diagnosis of pulmonary adenosquamous carcinoma with TTF-1/Napsin-A positive colonic metastases.
  • Patient achieved 42-month survival with a multidisciplinary, histology-guided treatment approach.
  • Intratumoral heterogeneity and phenotypic divergence observed across metastatic sites.

Conclusions:

  • Comprehensive tissue sampling and molecular characterization are crucial for accurate diagnosis and treatment planning.
  • Multidisciplinary management is essential for optimizing therapeutic sequencing in rare lung cancer presentations.
  • This case underscores the importance of histology-guided treatment in managing complex metastatic lung cancer.