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Updated: Sep 17, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Light-switchable divergent C-H activation and cross-coupling of cyclic ethers with aromatic aldehydes
Xumao Yang1, Quansheng Mou1, Mingxin Liu1
1The State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China. liumx@lzu.edu.cn.
None:
Divergent coupling reactions of cyclic ethers provide a powerful strategy for accessing high-value small molecules. We report a metal-free, light-regulated divergent method for C-H functionalization of cyclic ethers with aromatic aldehydes that selectively yields either hydroxyarylation or cross-dehydrogenative coupling products. Using tert-butyl peroxybenzoate as an oxidant and cyclic ether as both the solvent and the reductant, the reaction proceeds via a condition-dependent radical/ionic mechanism. This strategy enables sustainable access to diverse cyclic ether derivatives for medicinal and materials applications.
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