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Updated: Sep 17, 2025

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Glycemic Influences on Hypertrophic Cardiomyopathy Myocardium: Insights From Cardiac MRI Feature Tracking

Xin Peng1, Huaibi Huo2, Jin Gao1

  • 1Department of Radiology, The Third People's Hospital of Chengdu, Chengdu, China.

Journal of Magnetic Resonance Imaging : JMRI
|July 2, 2025
PubMed

Insights

Cardiac MRI feature tracking can identify myocardial damage in hypertrophic cardiomyopathy (HCM) patients with prediabetes or diabetes. Early glycemic control is crucial for managing HCM with glycemic disturbances.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Genetics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic disorder linked to left ventricular hypertrophy and increased cardiovascular risk.
  • Emerging research indicates that glycemic disturbances may worsen myocardial injury in HCM patients.

Purpose of the Study:

  • To assess the impact of prediabetes and diabetes on the myocardium of HCM patients.
  • Utilized cardiac MRI feature tracking (FT) for comprehensive myocardial evaluation.

Main Methods:

  • Retrospective study of 135 participants, categorized into HCM, prediabetes-HCM, diabetes-HCM, and control groups.
  • Employed 3.0T cardiac MRI with cine and late gadolinium enhancement sequences.
  • Assessed left ventricular global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), and their rates, along with endocardial right ventricular GLS and myocardial fibrosis using Medis software.

Main Results:

  • Left ventricular global radial strain (LV-GRS) was significantly lower in prediabetes-HCM and diabetes-HCM groups compared to HCM alone.
  • Reduced LV-GLS and endocardial right ventricular GLS were observed in patients with glycemic disturbances.
  • A significant negative correlation was found between LV-GRS and HbA1c, while LV-GLS positively correlated with LVMWT.

Conclusions:

  • Cardiac MRI feature tracking-derived strain parameters can detect early myocardial damage in HCM patients with prediabetes or diabetes.
  • Highlights the critical importance of timely glycemic control in managing HCM with associated glycemic issues.
Abstract

Keywords:
diabetesfeature trackinghypertrophic cardiomyopathyprediabetesstrain analysis

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