Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

679
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
679
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

24
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
24
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.2K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.2K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

33
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
33
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

586
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
586
Glaucoma: Overview01:25

Glaucoma: Overview

782
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
782

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Orbital and Ocular Venous Congestion: A Rare Manifestation of Hypervascular Paget Disease of the Bone.

Ophthalmic plastic and reconstructive surgery·2025
Same author

Retraction Note: Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity.

Scientific reports·2024
Same author

Ocular Siderosis.

International ophthalmology clinics·2024
Same author

Novel uses of complement inhibitors in myasthenia gravis-Two case reports.

Muscle & nerve·2024
Same author

The Effect of Sample Medication Use on Subsequent Anti-VEGF Agent Selection for Neovascular Age-Related Macular Degeneration.

Seminars in ophthalmology·2022
Same author

Restoration of Vision in Severe, Cicatricial, Ocular Surface Disease With the Boston Keratoprosthesis Type II.

American journal of ophthalmology·2022
Same journal

Home Tonometry and Perimetry: Addressing an Unmet Need in Glaucoma Care.

International ophthalmology clinics·2026
Same journal

Bleb Revision Techniques for Hypotony Maculopathy: A Review.

International ophthalmology clinics·2026
Same journal

Cyclodialysis Cleft Closure Following Suprachoroidal Spacer Implantation.

International ophthalmology clinics·2026
Same journal

Descemet Membrane Detachment During Ab-Interno Canaloplasty.

International ophthalmology clinics·2026
Same journal

Inflammatory Keratitis and IOP Spike After Repeat SLT in Pseudoexfoliation Glaucoma: Case Report and Literature Review.

International ophthalmology clinics·2026
Same journal

Beyond the Bottle: Lessons From the Laser in Glaucoma and Ocular Hypertension Trial.

International ophthalmology clinics·2026
See all related articles

Related Experiment Video

Updated: Sep 17, 2025

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

5.1K

Immune Recovery Uveitis: A Comprehensive Review.

Melissa Yuan1, Lucy H Young

  • 1Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.

International Ophthalmology Clinics
|July 2, 2025
PubMed
Summary
This summary is machine-generated.

Immune recovery uveitis (IRU) is a vision-threatening complication in HIV patients starting antiretroviral therapy. Early recognition and intervention are key to managing this inflammatory condition and preserving sight.

Keywords:
CMV retinitisHIV/AIDSimmune reconstitution inflammatory syndromeimmune recovery uveitis

More Related Videos

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

2.8K
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

343

Related Experiment Videos

Last Updated: Sep 17, 2025

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

5.1K
Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

2.8K
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

343

Area of Science:

  • Ophthalmology
  • Immunology
  • Infectious Diseases

Background:

  • Immune reconstitution inflammatory syndrome (IRIS) involves paradoxical worsening of infections during immune recovery.
  • Ocular IRIS, termed immune recovery uveitis (IRU), is a significant complication in HIV patients initiating highly active antiretroviral therapy (HAART).
  • IRU typically presents as posterior uveitis with vitritis, leading to vision loss and floaters.

Purpose of the Study:

  • To provide a comprehensive review of immune recovery uveitis.
  • To cover pathophysiology, clinical features, diagnosis, and management of IRU.
  • To highlight the importance of understanding IRU for managing HIV/AIDS patients.

Main Methods:

  • This is a review article.
  • Literature search on immune recovery uveitis and related conditions.
  • Synthesis of current knowledge on IRU.

Main Results:

  • IRU is characterized by posterior segment inflammation and vitritis.
  • It occurs in immunocompromised individuals, notably HIV patients on HAART.
  • Timely intervention is crucial for preventing vision loss.

Conclusions:

  • Understanding IRU is vital for ophthalmologists and infectious disease specialists.
  • Prompt diagnosis and management can prevent severe visual impairment.
  • Further research into IRU pathophysiology and treatment is warranted.