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Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization
Syed A H Zaidi1,2,3, Ruth B Caldwell4,5,6, Modesto A Rojas7,8,9
1Vascular Biology Center, Augusta University, Augusta, GA, 30912, USA.
Abstract:
Pathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and neurovascular injury. We show that OIR-induced activation of macrophage/microglial cells, retinal inflammation, and pathological RNV are mediated by increases in cholesterol ester (CE) formation due to activation of the acyl-CoA: Cholesterol Acyltransferase 1/Sterol O-Acyltransferase 1 (ACAT1/SOAT1) enzyme.
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