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Imaging cancer metabolism using magnetic resonance

Kevin M Brindle1

  • 1Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK. kmb1001@cam.ac.uk.

Npj Imaging
|July 3, 2025
PubMed

Insights

Metabolic imaging using hyperpolarized carbon-13 and deuterium-2H substrates can identify distinct tumor metabolic subtypes. This approach aids in selecting personalized cancer treatments and monitoring early treatment response.

Area of Science:

  • Oncology
  • Medical Imaging
  • Metabolic Profiling

Background:

  • Selecting optimal cancer treatments for individual patients is a significant clinical challenge.
  • Tumor metabolic subtypes, identified through transcriptome and metabolite profiling, exhibit varying therapeutic vulnerabilities.
  • Metabolic imaging offers a potential method to differentiate these subtypes and guide treatment selection.

Purpose of the Study:

  • To review the advantages and disadvantages of using magnetic resonance imaging (MRI) with hyperpolarized 13C- and 2H-labelled substrates for assessing tumor metabolism.
  • To discuss the role of metabolic imaging in identifying tumor subtypes and predicting treatment effectiveness.
  • To explore the utility of metabolic imaging in detecting early treatment response.

Main Methods:

  • Review of magnetic resonance imaging (MRI) techniques.
  • Discussion of hyperpolarized 13C-labelled substrates.
  • Discussion of hyperpolarized 2H-labelled substrates.

Main Results:

  • Metabolic imaging can distinguish tumors based on their metabolic profiles, suggesting different therapeutic vulnerabilities.
  • Early metabolic changes during treatment can be detected using metabolic imaging, indicating treatment response.
  • Hyperpolarized 13C and 2H MRI offer distinct advantages and disadvantages for metabolic assessment.

Conclusions:

  • Metabolic imaging holds promise for personalized oncology by enabling the selection of tailored treatments based on tumor metabolic subtypes.
  • This imaging modality can also serve as an early indicator of treatment efficacy.
  • Further research into hyperpolarized MRI techniques is warranted to optimize their clinical application in cancer management.

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