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Updated: Sep 17, 2025
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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
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Imaging cancer metabolism using magnetic resonance
1Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK. kmb1001@cam.ac.uk.
Npj Imaging
|July 3, 2025
Summary
Metabolic imaging using hyperpolarized carbon-13 and deuterium-2H substrates can identify distinct tumor metabolic subtypes. This approach aids in selecting personalized cancer treatments and monitoring early treatment response.
Area of Science:
- Oncology
- Medical Imaging
- Metabolic Profiling
Background:
- Selecting optimal cancer treatments for individual patients is a significant clinical challenge.
- Tumor metabolic subtypes, identified through transcriptome and metabolite profiling, exhibit varying therapeutic vulnerabilities.
- Metabolic imaging offers a potential method to differentiate these subtypes and guide treatment selection.
Purpose of the Study:
- To review the advantages and disadvantages of using magnetic resonance imaging (MRI) with hyperpolarized 13C- and 2H-labelled substrates for assessing tumor metabolism.
- To discuss the role of metabolic imaging in identifying tumor subtypes and predicting treatment effectiveness.
- To explore the utility of metabolic imaging in detecting early treatment response.
Main Methods:
- Review of magnetic resonance imaging (MRI) techniques.
- Discussion of hyperpolarized 13C-labelled substrates.
- Discussion of hyperpolarized 2H-labelled substrates.
Main Results:
- Metabolic imaging can distinguish tumors based on their metabolic profiles, suggesting different therapeutic vulnerabilities.
- Early metabolic changes during treatment can be detected using metabolic imaging, indicating treatment response.
- Hyperpolarized 13C and 2H MRI offer distinct advantages and disadvantages for metabolic assessment.
Conclusions:
- Metabolic imaging holds promise for personalized oncology by enabling the selection of tailored treatments based on tumor metabolic subtypes.
- This imaging modality can also serve as an early indicator of treatment efficacy.
- Further research into hyperpolarized MRI techniques is warranted to optimize their clinical application in cancer management.
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