Genomics of T-Cell Lymphomas With CD30/CD15 Co-Expression: Comparison With Anaplastic Large-Cell Lymphoma,...

Area of Science:

• Hematology
• Oncology
• Immunophenotyping

Background:

• The classification of mature T-cell neoplasms with CD30/CD15 coexpression remains challenging.
• Previous research suggested potential overlap with anaplastic large cell lymphoma (ALCL), particularly ALK-negative subtypes.

Purpose of the Study:

• To investigate the clinicopathologic, immunophenotypic, and molecular characteristics of T-cell lymphomas coexpressing CD30 and CD15.
• To compare these features with ALK/CD15-negative ALCL and existing literature.

Main Methods:

• Morphologic, immunophenotypic, and molecular analyses including immunohistochemistry, gene rearrangement studies, next-generation sequencing, and fluorescence in situ hybridization.
• Clinical data retrieval from submitting physicians.
• Classification into ALCL-like, Hodgkin-like, and PTCL-NOS-like variants.

Main Results:

• Most cases (28) showed T-cell marker loss and frequent alterations in JAK-STAT and PI3K-AKT-mTOR pathways.
• DUSP22 rearrangement was observed in 25% of evaluable cases.
• Cases exhibited features overlapping with ALK-negative ALCL but did not constitute a single defined entity.

Conclusions:

• T-cell neoplasms with CD30/CD15 coexpression share similarities with ALK-negative ALCL.
• These neoplasms are heterogeneous and do not fit into a single, well-defined category based on current histologic or genetic criteria.