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Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents

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A multi-objective optimization of degradable polymer vascular stents.

Mingkai Liang^1,2, Ruiqi Zhang³, Yuanming Gao^2,4

¹Innovation Center for Medical Engineering & Engineering Medicine, Hangzhou International Innovation Institute, Beihang University, Hangzhou, China.

Computer Methods in Biomechanics and Biomedical Engineering

|July 3, 2025

Summary

This study optimized degradable polymer stents to overcome insufficient support and fractures. The optimized design significantly improved mechanical support and effective working time, offering a promising strategy for enhanced stent performance.

Keywords:

Degradable polymer RBF model degradation performance multi-objective optimization structural optimization

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Area of Science:

Biomaterials Engineering
Medical Device Design
Polymer Science

Background:

Degradable polymer stents present challenges in mechanical support and premature fracture.
Existing designs often compromise between mechanical integrity and degradation profiles.

Purpose of the Study:

To enhance both mechanical support and degradation performance of polymer stents.
To develop an optimization strategy for improved stent functionality.

Main Methods:

Multi-objective structural optimization using three design variables.
Development of surrogate models (Radial Basis Function - RBF) to predict performance.
Application of a genetic algorithm to identify optimal design parameters.

Main Results:

The optimized polymer stent demonstrated a 52.1% increase in support force (F).
Effective working time (EWT) was enhanced by 27.4% in the optimized design.
Radial Basis Function (RBF) surrogate model showed high accuracy with prediction errors under 4%.

Conclusions:

The study presents an effective optimization strategy for polymer stent design.
Improved mechanical and degradation performance was achieved through multi-objective optimization.
The findings suggest a viable approach to enhance the clinical performance of degradable polymer stents.