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Updated: Sep 17, 2025

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
[Intracranial hypotension and secondary Chiaris malformation caused by spontaneous spinal fluid leakage]
Jeppe Damgren Vesterager1, Svetlana Rudnicka2, Carsten Reidies Bjarkam1
1Neurokirurgisk Afdeling, Aalborg Universitetshospital.
Abstract:
Charis Malformation type 1 (CM1) is a common incidental radiological finding, most often asymptomatic. Congenital CM1 is often due to a small fossa posterior, while acquired CM1 may be due to a change in pressure gradient over the foramen magnum. We present a case of a previously healthy patient with a several yearlong story of occipital headache, dizziness and nausea. MRI of cerebrum showed CM1, and repeated CT-myelography showed a CSF leak in relation to the right TH7 nerve root. The leak was operatively closed. After two months, the patient had no symptoms of CM1 or intracranial hypotension.
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