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Regression of Left Ventricular Hypertrophy After Aortic Valve Replacement with Sorin Freedom Solo and St. Jude Regent

Alen Karic1, Ervin Busevac1, Alma Krajnovic1

  • 1Clinic for Cardiovascular Surgery, Clinical Centre University of Sarajevo, Bosnia and Herzegovina.

Acta Informatica Medica : AIM : Journal of the Society for Medical Informatics of Bosnia & Herzegovina : Casopis Drustva Za Medicinsku Informatiku Bih
|July 3, 2025
PubMed

Insights

The Sorin Freedom Solo (SFS) bioprosthesis showed better hemodynamic performance and left ventricular hypertrophy regression than the St. Jude Regent (STJ) mechanical valve. Personalized valve selection is crucial for aortic stenosis patients.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Biomedical Engineering

Background:

  • Aortic stenosis (AS) is a common valvular disease in the elderly, primarily caused by degenerative calcification.
  • Progressive AS leads to left ventricular (LV) pressure overload, concentric hypertrophy, and myocardial remodeling.

Purpose of the Study:

  • To assess the regression of left ventricular (LV) hypertrophy after aortic valve replacement (AVR).
  • To compare the hemodynamic performance and clinical outcomes of two different prosthetic valves.

Main Methods:

  • Retrospective study of 150 patients undergoing AVR with Sorin Freedom Solo (SFS) stentless bioprosthesis or St. Jude Regent (STJ) mechanical valve.
  • Patients grouped by follow-up at six months, one year, and two years.
  • Evaluated transvalvular gradient, perioperative outcomes, and survival rates.

Main Results:

  • Both valves significantly reduced transvalvular gradients (p < 0.0001), with greater reduction for SFS.
  • Interventricular septum thickness decreased continuously in SFS patients; STJ showed reduction only in Group 2.
  • Left ventricular ejection fraction (LVEF) increased more significantly with SFS (p < 0.024), especially in Group 2.
  • No significant difference in overall mortality or survival rates between the two valves.

Conclusions:

  • SFS valve offers superior hemodynamic performance and LV hypertrophy regression, suitable for high-risk patients.
  • STJ valve provides stable long-term function, preferred for younger, lower-risk patients.
  • Personalized approach is essential for selecting appropriate prosthetic valves based on patient profiles.
Abstract

Keywords:
Regression of left ventricular hypertrophy of left ventricleSorin Freedom Soloaortic valve replacement

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