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Updated: Sep 17, 2025

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Association Between HLA-A*02:07 and Fixed Drug Eruption Caused by Sulfamethoxazole-Trimethoprim

Huyen Tran Thi1, Phuc Nguyen Hoang2, Phuong Pham Thi Minh3

  • 1Department of Dermatology and Venereology, Hanoi Medical University, Hanoi, Vietnam.

Materia Socio-Medica
|July 3, 2025
PubMed
Abstract

Insights

Fixed drug eruption (FDE) is linked to sulfamethoxazole-trimethoprim. The HLA-A*02:07 allele is associated with developing FDE, suggesting a potential genetic marker for risk assessment.

Area of Science:

  • Pharmacogenomics
  • Immunogenetics
  • Dermatology

Background:

  • Fixed drug eruption (FDE) is a recurring adverse drug reaction.
  • Sulfonamide antibiotics, particularly sulfamethoxazole-trimethoprim, are common triggers for FDE.
  • Human leukocyte antigen (HLA) associations with drug hypersensitivity are increasingly recognized.

Purpose of the Study:

  • To investigate the association between HLA-A alleles and fixed drug eruption (FDE) induced by sulfamethoxazole-trimethoprim.
  • To identify potential genetic markers for sulfamethoxazole-trimethoprim-induced FDE.

Main Methods:

  • A cross-sectional study involving 30 FDE patients and 30 healthy controls.
  • Human leukocyte antigen (HLA)-A typing performed using polymerase chain reaction with sequence-specific oligonucleotides (PCR-SSO).

Main Results:

  • The HLA-A*02:07 allele was significantly more frequent in FDE patients (40%) compared to controls (16.67%, p < 0.05).
  • Individuals with the HLA-A*02:07 allele had a 3.33-fold increased likelihood of developing FDE from sulfamethoxazole-trimethoprim.
  • No significant differences in other HLA-A allele frequencies were observed between groups.

Conclusions:

  • An association exists between the HLA-A*02:07 allele and fixed drug eruption (FDE) caused by sulfamethoxazole-trimethoprim in the Vietnamese population.
  • Pre-prescription screening for HLA-A*02:07 may help identify individuals at risk for FDE.
Keywords:
Fixed drug eruptionHLA-A*02:07Human leukocyte antigenSulfamethoxazole-trimethoprim

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