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Related Concept Videos

Anatomy of the Brain: Major Regions01:20

Anatomy of the Brain: Major Regions

The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
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Related Experiment Video

Updated: Jun 19, 2026

In vivo Imaging of Deep Cortical Layers using a Microprism
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Yale Brain Atlas to interactively explore multimodal structural and functional neuroimaging data.

Evan Collins1,2,3, Omar Chishti1,4, Hari McGrath1,5

  • 1Department of Neurosurgery, Yale School of Medicine, New Haven, CT, United States.

Frontiers in Network Physiology
|July 3, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces the Yale Brain Atlas, an interactive tool and database for exploring brain structure and function. It enables scalable analysis of multimodal neuroimaging data to understand brain organization

Keywords:
brain atlasconnectivityfMRInetwork physiologyneuroimagingstructure-functionweb tool

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Computational Neuroscience

Background:

  • Understanding the human brain's structure-function relationship is crucial for explaining cognition, emotion, and behavior.
  • Precise localization and analysis of neuroimaging data are essential for brain research.

Purpose of the Study:

  • To introduce an interactive web tool and database for the Yale Brain Atlas.
  • To facilitate precise localization and generalizable analyses of multimodal neuroimaging data.
  • To support the investigation of brain structure-function relationships.

Main Methods:

  • Developed a high-resolution anatomical parcellation (Yale Brain Atlas).
  • Integrated structural data (white matter connectomes, cortical thickness) from the Human Connectome Project.
  • Incorporated functional data (resting-state fMRI, task-specific fMRI activation) from meta-analytic resources (Neurosynth, NeuroQuery), creating Parcelsynth and ParcelQuery.

Main Results:

  • The web tool allows parcel-level exploration of structural and functional data.
  • Data includes white matter connectomes (1,065 subjects), cortical thickness (200 subjects), and fMRI connectivity matrices (34 subjects).
  • Functional data was translated into Yale Brain Atlas space with 334 function-specific terms.

Conclusions:

  • The Yale Brain Atlas web tool and database enable scalable, interactive exploration of multimodal neuroimaging data.
  • This resource aids in understanding the complex relationships between brain structure and function.
  • Facilitates generalized analyses across diverse neuroimaging datasets.