Related Experiment Video
Updated: May 28, 2026

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
An update on the network theory of epilepsy
Hitten P Zaveri1, Steven M Pincus2, Robert B Duckrow1
1Departments of Neurology, Yale University, New Haven, CT, United States.
None:
We provide an understanding of the network theory of epilepsy based on an interpretation of temporal, spatial, spectral and connectivity evaluations of background intracranial electroencephalogram (EEG) recordings. The background intracranial EEG recordings were acquired from patients with medically intractable epilepsy undergoing evaluation for epilepsy surgery. We argue that our results suggest, in the main, the presence of a two-node network with one of the nodes being the seizure onset area, and the second the thalamus. We hypothesize seizures arise from the interaction of these two nodes under a specific set of circumstances.
Related Concept Videos
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures l: Introduction
Epilepsy ll: Types
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Overview of Synapses
Seizures ll: Types

