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Updated: Sep 17, 2025

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
Published on: October 7, 2021
[Polyneuropathies - a practical overview]
Marisa Blanquet1,2, Andrea M Humm1,3
1Neuromuskuläres Zentrum, Universitätsklinik fur Neurologie, Inselspital Bern, Bern.
Polyneuropathies present diverse symptoms and causes. This guide offers a practical approach to diagnosis and treatment, highlighting red flags for urgent specialist referral.
Area of Science:
- Neurology
- Clinical Medicine
Background:
- Polyneuropathies are prevalent neurological disorders with varied clinical manifestations.
- Numerous underlying etiologies contribute to the development of polyneuropathies.
Purpose of the Study:
- To provide a practice-oriented overview of polyneuropathy symptoms and causes.
- To outline a systematic, step-by-step diagnostic strategy for polyneuropathies.
- To emphasize the identification of red flags necessitating prompt specialist evaluation and to briefly discuss treatment options.
Main Methods:
- Literature review and synthesis of current clinical guidelines.
- Analysis of diagnostic criteria and red flag indicators.
- Summary of established and emerging treatment modalities.
Main Results:
- Detailed description of common and uncommon polyneuropathy symptoms.
- Categorization of major etiological factors, including metabolic, toxic, infectious, and hereditary causes.
- Presentation of a structured diagnostic algorithm incorporating clinical examination, laboratory tests, and electrophysiological studies.
Conclusions:
- Early identification of specific symptoms and red flags is crucial for timely diagnosis.
- A systematic diagnostic approach ensures comprehensive evaluation of polyneuropathies.
- Appropriate management based on etiology leads to improved patient outcomes.
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