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Imaging-based Surgical Site Infection Detection Using Artificial Intelligence
Hala Muaddi1, Ashok Choudhary2, Frank Lee1
1Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, MN.
Annals of Surgery
|July 3, 2025
Summary
An artificial intelligence pipeline effectively assesses patient-submitted wound images for surgical site infections (SSIs). This AI tool aids in early detection, reducing clinician workload and improving postoperative care outcomes.
Area of Science:
- Medical Artificial Intelligence
- Digital Health
- Surgical Site Infection Detection
Background:
- Increasing outpatient surgeries and remote monitoring generate significant administrative tasks for clinicians.
- Early detection of surgical site infections (SSIs) is critical for minimizing postoperative complications.
- Patient-submitted wound images via online portals are becoming more common.
Purpose of the Study:
- To create an artificial intelligence (AI)-based system for evaluating and prioritizing patient-submitted postoperative wound images.
- To automate the assessment of wound images and detect potential surgical site infections (SSIs).
Main Methods:
- Developed a two-stage AI model for incision detection and SSI detection in postoperative wound images.
- Utilized a dataset of 6060 patient images from Mayo Clinic hospitals (2019-2022), including SSI outcomes from the National Surgical Quality Improvement Program (NSQIP).
- Evaluated four pretrained architectures using cross-validation, data augmentation, and image quality assessment, including sensitivity analysis across racial groups.
Main Results:
- The Vision Transformer model achieved high accuracy in incision detection (0.94) and SSI detection (0.73).
- The AI pipeline demonstrated robust performance in image quality assessment.
- Performance was consistent across different racial subgroups, indicating equitable effectiveness.
Conclusions:
- The developed AI pipeline shows significant potential for automating the assessment of postoperative wound images.
- This technology can effectively aid in the early detection of surgical site infections (SSIs).
- The AI system promises to reduce clinician workload and enhance the quality of postoperative patient care.

