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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Sep 17, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Correlating 10-2 Visual Field Loss with Structural and Angiographic Parameters in Advanced Glaucoma.

Kübra Atay Dinçer1, Metehan Karaatlı1,2, Onur Özalp1

  • 1Department of Ophthalmology, Eskişehir Osmangazi University Medical School, Meşelik Kampüsü, Odunpazarı, Eskisehir, Turkey.

Ophthalmology and Therapy
|July 3, 2025
PubMed
Summary

Optical coherence tomography angiography (OCTA) shows that parafoveal superficial capillary plexus vessel density (SCP-VD) and ganglion cell complex (GCC) thickness correlate with visual field MD in advanced glaucoma. These OCTA parameters may help monitor disease progression when visual field testing is difficult.

Keywords:
Advanced glaucomaGanglion cell complexOct angiographyRNFLVessel densityVisual field

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Advanced glaucoma significantly impacts visual function.
  • Optical coherence tomography angiography (OCTA) offers novel insights into retinal vasculature.
  • Understanding vascular changes in glaucoma is crucial for disease management.

Purpose of the Study:

  • To investigate the correlation between OCTA-derived vascular parameters and functional/structural measures in advanced glaucoma.
  • To explore the relationship between OCTA parameters, central visual field (10-2 VF) mean deviation (MD), ganglion cell complex (GCC) thickness, and retinal nerve fiber layer (RNFL) thickness.
  • To identify potential surrogate markers for monitoring glaucoma progression.

Main Methods:

  • Retrospective, cross-sectional study of 28 eyes from 23 patients with advanced glaucoma (VF MD worse than -12 dB).
  • Comprehensive ophthalmic examinations including OCT, OCTA, and 10-2 VF testing.
  • Pearson's correlation analysis to assess relationships between vascular, structural, and functional parameters.

Main Results:

  • Significant positive correlations were observed between GCC thickness and 10-2 VF MD (r=0.529, p=0.005).
  • Parafoveal superficial capillary plexus vessel density (SCP-VD) positively correlated with 10-2 VF MD (r=0.549, p=0.002).
  • Macular SCP vessel area density correlated with RNFL thickness (r=0.429, p=0.036); mean vessel length in the optic nerve head layer negatively correlated with 10-2 VF MD (r=-0.528, p=0.003).
  • Quadrant-wise analysis showed associations between SCP-VD and GCC/RNFL thickness in the superior hemifield, and deep capillary plexus vessel density and RNFL thickness in the inferior hemifield.

Conclusions:

  • Parafoveal SCP-VD and GCC thickness demonstrate significant correlations with 10-2 VF MD in advanced glaucoma.
  • These OCTA-derived parameters may serve as valuable surrogate markers for monitoring central visual function.
  • OCTA parameters can aid in tracking disease progression, especially when standard visual field testing is challenging.